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What is (gMG)?

generalizedMYASTHENIAGRAVIS

Myasthenia Gravis is a rare, chronic autoimmune neuromuscular disease.1-4 That targets the neuromuscular junction.1

It is characterized by fluctuating and fatigable skeletal muscle weakness.1-4 gMG can affect many muscle groups, including ocular, bulbar, limb, axial and respiratory muscles.1-4

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Patient Classes

Class I
Any ocular muscle weakness; may have weakness of eye closure; all other muscle strength is normal
Class II
Mild weakness, affecting muscles other than the ocular muscles; may also have ocular muscle weakness of any severity
Class III
Moderate weakness, affecting muscles other than the ocular muscles; may also have ocular muscle weakness of any severity
Class IV
Severe weakness, affecting muscles other than the ocular muscles; may also have ocular muscle weakness of any severity
Class V
Intubation, with or without mechanical ventilation, except when employed during routine post-operative management
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Levels of MG disease control5

  • Full disease control

    No disease activity,no residual symptoms

  • Full disease controlwith no detectable disease activity

    Minimal residualsymptoms with stability, incomplete remission

  • Incomplete diseasecontrol with disease activity

    Instability, deterioration, fluctuation with residual symptoms, continuous new or developing symptoms, +/- fluctuations. +/- crises

  • No disease control with high disease activity, including refractory MG

    Continuous symptoms with or without crises or deteriorations, resistance to therapy

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References:

  • 1. Conti-Fine BM et al. J Clin Invest 2006;116:2843-54.
  • 2. Mantegazza R et al. Neuropsychiatr Dis Treat 2011;7:151-60.
  • 3. Thanvi BR et al. Postgrad Med J 2004;80:690-700.
  • 4. Juel VC et al. Orphanet J Rare Dis 2007;2:44.
  • 5. Wiendl H et al.. Guidelines for the management of myasthenic syndromes. Therap Adv Neurol Disord 2023 .